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    znf281a zinc finger protein 281a [ Danio rerio (zebrafish) ]

    Gene ID: 100005963, updated on 27-Mar-2024

    Summary

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    Official Symbol
    znf281aprovided by ZNC
    Official Full Name
    zinc finger protein 281aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-131126-34
    See related
    Ensembl:ENSDARG00000000567 AllianceGenome:ZFIN:ZDB-GENE-131126-34
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-197i23.1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in nucleus. Orthologous to human ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (38762886..38784003, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (38621022..38642300, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene MAGUK p55 scaffold protein 3a Neighboring gene si:ch211-198m17.1 Neighboring gene potassium inwardly rectifying channel subfamily J member 19a Neighboring gene si:dkey-106c17.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 281-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      38762886..38784003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474700.1 → XP_021330375.1  zinc finger protein 281-like isoform X2

      UniProtKB/TrEMBL
      A0A8M9QAI3
      Conserved Domains (3) summary
      sd00017
      Location:170 → 190
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:168 → 190
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:238 → 263
      zf-H2C2_2; Zinc-finger double domain

    2. XM_001922353.7 → XP_001922388.3  zinc finger protein 281-like isoform X1

      UniProtKB/TrEMBL
      A0A8M1QLK4, E7F1T3
      Related
      ENSDARP00000128940.1, ENSDART00000155518.2
      Conserved Domains (4) summary
      COG5048
      Location:194 → 292
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:204 → 224
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:202 → 224
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:272 → 297
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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